Frailty is an aging-related state of decreased physiological reserve that results in increased vulnerability to poor health outcomes, worsening mobility and disability, hospitalizations, and mortality (1). Long recognized within the field of geriatrics as a clinical syndrome, frailty occurs in approximately 25% of people aged 65 and over (2). Frailty also contributes greatly to cost of care. The estimated annual cost directly attributed to frailty is more than $14,000 per patient after controlling for other variables (3).
People who are frail have a decreased ability to maintain or return to homeostasis after stressful events or aggressive interventions. This often leads to loss of independence (4). Compared to non-frail patients, they are 15% more likely to develop inpatient complications, and in the year following treatments for critical illness, have 30% increased disability in daily activities (1,5). For older adults, frailty may be a better predictor of mortality than age. It doubles the risk of in-hospital mortality and increases the risk of one-year mortality by 50% (5,6).
Even though frailty is a measurable phenotype that can be identified with standardized measures, such as unintentional weight loss of 10 pounds in the past year, these performance measures are not routinely captured in clinical encounters (7). Frailty is also not captured in administrative claims databases. But, validated claims-based algorithms have shown good discrimination of frailty and high predictive ability with adverse health outcomes. These algorithms present a powerful tool to enable provider identification and risk assessment of frail patients (7,8).
Early identification of frailty via predictive analytics is vital, as the evidence shows that frailty can be managed and reduced. Interventions designed to improve nutrition, stimulate cognition, and promote physical activity can reduce frailty between 35 and 45% (9,10). Frailty also has greater reversibility than disability, and prioritizing screening can provide critical information to identify poor prognosis and reversible risk factors.